Chronic Kidney diseases: Role of Vitamin-K and Vitamin-D

Vinod Kumar Varapete (1) , Ravindra B N (2) , Jerin S Shaji (3) , Yaseen Mulla (4) , Jiss P Jose (5) , Alex Dominic (6) , Prolay Paul (7) , Sayantan Ghosh (8)
(1) Pharm D Intern , India
(2) Assistant Professor , India
(3) Pharm D Intern , India
(4) Pharm D Intern , India
(5) Pharm D Intern , India
(6) Pharm D Intern , India
(7) Pharm D Intern , India
(8) Pharm D Intern , India

Abstract

Chronic kidney disease is the most common form of kidney disease and high blood pressure is the most common cause the pressure on the glomeruli increases due to high blood pressure which can prove to be very dangerous. Lack in VITAMIN D isn't restricted to the dynamic chemical, calcitriol (25-hydroxycholecalciferol) is likewise insufficient in many patients with constant kidney sickness (CKD), free of their fundamental renal capacity. Diminishes in calcitriol happen generally right off the bat in the movement of kidney illness and may originate before the increment in PTH. These progressions in calcitriol and PTH add to the upkeep of moderately ordinary serum and calcium fixations until the glomerular filtration rate (GFR) diminishes to <20–25%; nonetheless, the outcome is the potential advancement of bone and vascular sickness. Vitamin K intake and long-term vitamin K status are expressed by a high percentage of undercarboxylated OC (uOC). Vitamin D, which is needed for uOC development, and parathyroid hormone (PTH), which is often elevated in patients with CKD, are also affected by osteocalcin levels. Therefore, elevated serum uOC is present in patients with chronic kidney disease (CKD) with hyperparathyroidism, but this does not generally mean that they are deficient in vitamin K.

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Authors

Vinod Kumar Varapete
varaphatevinod@gmail.com (Primary Contact)
Ravindra B N
Jerin S Shaji
Yaseen Mulla
Jiss P Jose
Alex Dominic
Prolay Paul
Sayantan Ghosh
Author Biographies

Vinod Kumar Varapete, Pharm D Intern

Pharm D Intern,

Department of Pharmacy Practice

Sri Adichunchanagiri College of Pharmacy,

B G Nagara, Karnataka- 571448

Ravindra B N, Assistant Professor

M- Pharm, Assistant Professor,

Department of Pharmacy Practice

Sri Adichunchanagiri College of Pharmacy,

B G Nagara, Karnataka- 571448 

Jerin S Shaji, Pharm D Intern

Pharm D Intern

Department of Pharmacy Practice

Sri Adichunchanagiri College of Pharmacy,

B G Nagara, Karnataka- 571448 

Yaseen Mulla, Pharm D Intern

Pharm D Intern,

Department of Pharmacy Practice

Sri Adichunchanagiri College of Pharmacy,

B G Nagara, Karnataka- 571448 

Jiss P Jose, Pharm D Intern

Pharm D Intern,

Department of Pharmacy Practice

Sri Adichunchanagiri College of Pharmacy,

B G Nagara, Karnataka- 571448 

Alex Dominic, Pharm D Intern

Pharm D Intern,

Department of Pharmacy Practice

Sri Adichunchanagiri College of Pharmacy,

B G Nagara, Karnataka- 571448 

Prolay Paul, Pharm D Intern

Pharm D Intern,

Department of Pharmacy Practice

Sri Adichunchanagiri College of Pharmacy,

B G Nagara, Karnataka- 571448 

Sayantan Ghosh, Pharm D Intern

Pharm D Intern,

Department of Pharmacy Practice

Sri Adichunchanagiri College of Pharmacy,

B G Nagara, Karnataka- 571448 

Varapete, V. K., B N, R. ., S Shaji, J. ., Mulla, Y., P Jose, J., Dominic, A., Paul, P., & Ghosh, S. . (2021). Chronic Kidney diseases: Role of Vitamin-K and Vitamin-D. Journal of Current Medical Research and Opinion, 4(03), 852−866. https://doi.org/10.15520/jcmro.v4i03.401
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