Efficacy of Tretinoin Cream 0.05% with Adapalene Gel 0.1% for the Treatment of Plane Warts
Abstract
Background: Cutaneous viral warts (CVW) are a common and often recalcitrant condition[1]. This study aimed to investigate the efficacy of a combination therapy using Tretinoin Cream 0.05% and Adapalene Gel 0.1% for the treatment of cutaneous plane warts.
Methods: an open therapeutic trial adapted at private clinics in Mosul, Iraq, between January 2020 and June 2024. A total of 102 patients with plane warts, aged 8 to 50 years, of both sex was included. Patients were treated with a combination of Tretinoin Cream 0.05% used at night every other day and Adapalene Gel 0.1% used twice daily for 8 weeks.
Results: The findings suggest that the combination therapy is an effective and well-tolerated treatment for plane warts. At 8 weeks, excellent response rates were observed in 82% of patients with 1-10 lesions, 54% of patients with 11-20 lesions, and 39% of patients with more than 20 lesions. The most common side effects were erythema (10.8%), scaling (22.5%), burning (8.8%), and itching (8.8%).
Conclusion: This study provides evidence that the combination of Tretinoin Cream 0.05% and Adapalene Gel 0.1% is an effective and well-tolerated treatment for plane warts, with a high response rate in patients with varying lesion counts.
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