Evaluation of Biological Activity of Natural Compounds: Antihyperglycemic, Anti-Inflammatory, Analgesic and Anticoagulant Activity

Hawraa Ahmed Kazem Abdul Hussein (1) , Abeer Alaa Muhammad Hassan (2) , Taghreed Ali Jabbar Abd (3) , Muhammad Abd Ali Muhammad Hussein (4) , Firas Jalal Abdul Rasoul Hassan (5)
(1) College of Science for Girls, University of Babylon, Iraq. , Iraq
(2) College of Science for Girls, University of Babylon , Iraq. , Iraq
(3) College of Science for Girls, University of Babylon, Iraq. , Iraq
(4) College of Science, University of Babylon, Iraq. , Iraq
(5) College of Science, University of Kufa, Iraq. , Iraq

Abstract

All forms of life contain natural compounds, each of which has a unique structure and can be found in a variety of forms. Tannins, anthocyanins, and alkaloids are only some of the metabolites that function as a defence mechanism in living organisms. These metabolites are obviously molecules that are of interest to the food, cosmetic, and pharmaceutical sectors. Plants, microbes, and insects are all examples of suppliers of biomolecules that have a wide range of actions, yet in many cases, these biomolecules have not been thoroughly investigated. In order to make use of these molecules for a variety of purposes, it is necessary to have a solid understanding of their structure, concentrations, and the potential for biological activity. Since the 1950s, in vitro techniques have been developed that measure the biological activity of the molecules of interest without the presence of the molecules themselves. As of right now, a variety of strategies have arisen in order to overcome some of the restrictions that these old procedures have, primarily through reductions in the amount of time and money required. The purpose of this study is to provide an overview of the interactions between herbal drugs that have been used for the treatment of blood coagulation, as well as the effect of herbal pharmaceuticals on anticoagulant therapy in secondary metabolites composed of medicinal plants. This review is comprised of multiple papers. It has been demonstrated that tridax procumbent possesses a multitude of active constitutions that have therapeutic value and are a significant source of anticoagulant treatment. The urgent requirement to expand the capacity for analysis of an increasing number of biomolecules that have been reported is the driving force behind the continued appearance of these developing technologies. Inflammation is a pathologic condition that encompasses a wide variety of diseases, including rheumatic and immune-mediated ailments, diabetes, cardiovascular accidents, and a variety of other conditions.

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References

Kingston, D.G.I. Modern natural products drug discovery and its relevance to biodiversity conservation. J. Nat. Prod. 2011, 74, 496–511.

Batool, M.; Ahmad, B.; Choi, S. A Structure-Based Drug Discovery Paradigm. Int. J. Mol. Sci. 2019, 20, 2783.

Martin, Y.C.; Kofron, J.L.; Traphagen, L.M. Do structurally similar molecules have similar biological activity? J. Med. Chem. 2002, 45, 4350–4358.

Rasoanaivo, P.; Wright, C.W.; Willcox, M.L.; Gilbert, B. Whole plant extracts versus single compounds for the treatment of malaria: Synergy and positive interactions. Malar. J. 2011, 10 (Suppl. S1), S4.

Gilbert, B.; Alves, L. Synergy in plant medicines. Curr. Med. Chem. 2003, 10, 13–20.

Vinken, M.; Blaauboer, B.J. In vitro testing of basal cytotoxicity: Establishment of an adverse outcome pathway from chemical insult to cell death. Toxicol. Vitr. 2017, 39, 104–110.

Di Nunzio, M.; Valli, V.; Tomás-Cobos, L.; Tomás-Chisbert, T.; Murgui-Bosch, L.; Danesi, F.; Bordoni, A. Is cytotoxicity a determinant of the different in vitro and in vivo effects of bioactives? BMC Complement. Altern. Med. 2017, 17, 453.

Ling, T.; Lang, W.H.; Maier, J.; Quintana Centurion, M.; Rivas, F. Cytostatic and Cytotoxic Natural Products against Cancer Cell Models. Molecules 2019, 24, 2012.

Jablonská, E.; Kubásek, J.; Vojtˇech, D.; Ruml, T.; Lipov, J. Test conditions can significantly affect the results of in vitro cytotoxicity testing of degradable metallic biomaterials. Sci. Rep. 2021, 11, 6628.

Thete, M.; Dilip, A. Recent advances and methods for in-vitro evaluation of antidiabetic activity: A review. Int. J. Eng. Appl. Sci. Technol. 2020, 4, 194–198.

Gromova, L.V.; Fetissov, S.O.; Gruzdkov, A.A. Mechanisms of glucose absorption in the small intestine in health and metabolic diseases and their role in appetite regulation. Nutrients 2021, 13, 2474.

Xue, B.; Kim, Y.-B.; Lee, A.; Toschi, E.; Bonner-Weir, S.; Kahn, C.R.; Neel, B.G.; Kahn, B.B. Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance. J. Biol. Chem. 2007, 282, 23829–23840.

Deacon, C.F. Physiology and Pharmacology of DPP-4 in Glucose Homeostasis and the Treatment of Type 2 Diabetes. Front. Endocrinol. 2019, 10, 80.

Gladis Raja Malar Chelladurai, Chellaram Chinnachamy, Alpha amylase and alpha glucosidase inhibitory effects of aqueous stem extract of Salacia oblonga and its GC-MS analysis. Brazillian Journal of Pharmaceutical Sciences. 2018; 3-5.

De Gouveia NM, Alves FV, Furtado FB, Scherer DL, Mundim AV, Espindola FS. An in vitro and in vivo study of the α-amylase activity of phaseolamin. J Med Food. 2014 Aug;17(8);915-20. 16.

Fatemeh Ghorbani. Masoud sadeghi, Abbas aghaei, Arezou ghahghaei, Study of α-Amylase Inhibitors among Different Bean Cultivars and Evaluation of their Effectiveness Compared with a Commercial Product using In Vitro/In Vivo Experimental Systems. Journal of Research in Medical and Dental Science. 2018; 6(1); 381-383.

Muhammad Nawaz, Muhammad Taha, Faiza Quershi, Nisar Ullah, Manikandan Selvaraj, Sumaira Shahzad, Sridevi Chigurupati, Abdul Waheed and Fadiah Ammar Almutairi, Structural Elucidation, Molecular Docking, α-Amylase and αGlucosidase Inhibition Studies of 5-AminoNicotinic Acid Derivatives.” BMC Chemistry. 2020; 14(1).

Kajaria D, Ranjana, Tripathi J, Tripathi YB, Tiwari S. In-vitro α amylase and glycosidase inhibitory effect of ethanolic extract of antiasthmatic drug - Shirishadi. J Adv Pharm Technol Res. 2013; 4(4); 206-209.

Ondua, M.; Njoya, E.M.; Abdalla, M.A.; McGaw, L.J. Anti-inflammatory and antioxidant properties of leaf extracts of eleven South African medicinal plants used traditionally to treat inflammation. J. Ethnopharmacol. 2019, 234, 27–35.

Chan, P.-M.; Tan, Y.-S.; Chua, K.-H.; Sabaratnam, V.; Kuppusamy, U.R. Attenuation of Inflammatory Mediators (TNF-α and Nitric Oxide) and Up-Regulation of IL-10 by Wild and Domesticated Basidiocarps of Amauroderma rugosum (Blume & T. Nees) Torrend in LPS-Stimulated RAW264.7 Cells. PLoS ONE 2015, 10, e0139593.

Abdulkhaleq, L.A.; Assi, M.A.; Abdullah, R.; Zamri-Saad, M.; Taufiq-Yap, Y.H.; Hezmee, M.N.M. The crucial roles of inflammatory mediators in inflammation: A review. Vet. World 2018, 11, 627–635.

Oguntibeju, O.O. Medicinal plants with anti-inflammatory activities from selected countries and regions of Africa. J. Inflamm. Res. 2018, 11, 307–317.

Alamgir, A.N.M. Phytoconstituents—Active and inert constituents, metabolic pathways, chemistry and application of phytoconstituents, primary metabolic products, and bioactive compounds of primary metabolic origin. In Therapeutic Use of Medicinal Plants and Their Extracts: Volume 2; Progress in Drug Research; Springer: Cham, Switzerland, 2018; Volume 74, pp. 25–164, ISBN 978-3-319-92386-4.

O ˙zarowski, M.; Karpi ´nski, T.M. Extracts and Flavonoids of Passiflora Species as Promising Anti-inflammatory and Antioxidant Substances. Curr. Pharm. Des. 2021, 27, 2582–2604.

Xu, Y.-B.; Chen, G.-L.; Guo, M.-Q. Antioxidant and Anti-Inflammatory Activities of the Crude Extracts of Moringa oleifera from Kenya and Their Correlations with Flavonoids. Antioxidants 2019, 8, 296.

Marzouk, B.; Marzouk, Z.; Haloui, E.; Fenina, N.; Bouraoui, A.; Aouni, M. Screening of analgesic and anti-inflammatory activities of Citrullus colocynthis from southern Tunisia. J. Ethnopharmacol. 2010, 128, 15–19. [CrossRef]

Koyyalagunta, D. Opioid Analgesics. In Pain Management; Elsevier: Amsterdam, The Netherlands, 2007; pp. 939–964, ISBN 9780721603346

Vardanyan, R.S.; Hruby, V.J. Analgesics. In Synthesis of Essential Drugs; Elsevier: Amsterdam, The Netherlands, 2006; pp. 19–55,

Sharma, A. Various biological activities of DHA derivatives. In Dehydroacetic Acid and Its Derivatives; Elsevier: Amsterdam, The Netherlands, 2017; pp. 81–118,

Sullivan, K.R.; Cammarano, W.B.; Wiener-Kronish, J.P. Analgesics, tranquilizers, and sedatives. In Cardiac Intensive Care; Elsevier: Amsterdam, The Netherlands, 2010; pp. 504–515, ISBN 9781416037736.

Eguchi, K.; Makimura, M.; Murakoshi, Y. Properties of opiate receptor binding in an opiate tolerant state. In Advances in Endogenous and Exogenous Opioids; Elsevier: Amsterdam, The Netherlands, 1981; pp. 428–430.

Yunes, R.A.; Filho, V.C.; Ferreira, J.; Calixto, J.B. The use of natural products as sources of new analgesic drugs. In Bioactive Natural Products (Part K); Studies in natural products chemistry; Elsevier: Amsterdam, The Netherlands, 2005; Volume 30, pp. 191–212,

Marzouk, B.; Marzouk, Z.; Haloui, E.; Fenina, N.; Bouraoui, A.; Aouni, M. Screening of analgesic and anti-inflammatory activities of Citrullus colocynthis from southern Tunisia. J. Ethnopharmacol. 2010, 128, 15–19.

Vogel, H.G. (Ed.) Drug Discovery and Evaluation: Pharmacological Assays; Springer: Berlin/Heidelberg, Germany, 2008; ISBN 978-3-540-70995-4

Authors

Hawraa Ahmed Kazem Abdul Hussein
Abeer Alaa Muhammad Hassan
Taghreed Ali Jabbar Abd
Muhammad Abd Ali Muhammad Hussein
Firas Jalal Abdul Rasoul Hassan
Hussein , H. A. K. A. ., Hassan , A. A. M. ., Abd, T. A. J., Muhammad Hussein , M. A. A. ., & Hassan, F. J. A. R. . (2024). Evaluation of Biological Activity of Natural Compounds: Antihyperglycemic, Anti-Inflammatory, Analgesic and Anticoagulant Activity. Journal of Current Medical Research and Opinion, 7(04), 2275–2284. https://doi.org/10.52845/CMRO/2024/7-4-7

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