A Myeloproliferative Syndrome Revealed by An Eosinophilic Lung

Abstract

Hypereosinophilic syndrome (HES) is defined by eosinophilia greater than 1.5 G/L persisting for more than six months and associated with specific visceral damage (cardiac, neurological, pulmonary, etc.), after elimination of the “classic” causes of hypereosinophilia. .

We report the case of a 25-year-old man who presented to the emergency room for acute-onset febrile dyspnea, transferred to the pulmonology department for suspected Covid, an FNS performed as part of a routine check-up. reveals a leukocytosis of more than 65 G/L including 80% eosinophils, an etiological search launched, first eliminated the secondary causes and firstly the allergies, led to a cytogenetic analysis which came back positive in favor of an eosinophilic myeloproliferative syndrome with the demonstration of a FLIPI-PDGFRA transcript, he benefited from targeted therapy with a total regression of the symptoms followed by recurrent cytogenetics.